Integrin alpha 6/CD49f Antibody (6B4) Summary
Clone 6B4 is a mouse monoclonal IgG1, kappa antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a synthetic peptide corresponding to a 34 amino acid stretch in the cytoplasmic domain of integrin alpha 6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK coupled to keyhole limpet hemocyanin.
Clone 6B4 recognizes specifically the cytoplasmic domain of integrin subunit alpha 6B. 6B4 stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands.
Tissue culture supernatant
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.09% Sodium Azide
Tissue culture supernatant
- Immunocytochemistry/Immunofluorescence 1:10-1:500
- Immunohistochemistry 1:2-1:10
- Immunohistochemistry-Frozen 1:2-1:10
Human. A broad species reactivity is expected because of the conserved nature of the epitope.
Alternate Names for Integrin alpha 6/CD49f Antibody (6B4)
- CD49 antigen-like family member F
- CD49f antigen
- Integrin alpha 6
- integrin alpha-6
- integrin alpha6B
- integrin, alpha 6
- Platelet gpl
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth,
differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha 6, two cytoplasmic variants, A and B, have been identified.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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