Integrin alpha 5/CD49e Antibody (MFR5 (5H10))

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Flow Cytometry: Integrin alpha 5/CD49e Antibody (MFR5 (5H10)) [NB100-64907] - Analysis using the FITC conjugate of NB100-64907. Staining of mouse peripheral blood lymphocytes.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, IHC, IHC-Fr
Clone
MFR5 (5H10)
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Integrin alpha 5/CD49e Antibody (MFR5 (5H10)) Summary

Immunogen
Mouse MC/9 cell line
Localization
Type I membrane protein.
Specificity
NB100-64907 recognizes murine integrin alpha 5 (CD49e), which associates with the beta 1 integrin (CD29) to form the fibronectin receptor CD49e/CD29 (VLA-5). VLA-5 plays an important role in cell adhesion and migration and is expressed by mast cells, thymocytes, T-cells and monocytes. Clone MFR5(5H10) has been reported to block CD49e mediated function.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
ITGA5
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:25
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Integrin alpha 5/CD49e Antibody (MFR5 (5H10))

  • CD49 antigen-like family member E
  • CD49e antigen
  • CD49e
  • Fibronectin receptor subunit alpha
  • fibronectin receptor, alpha subunit
  • FNRAVLA5A
  • Integrin alpha 5
  • integrin alpha-5
  • Integrin alpha-F
  • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
  • ITGA5
  • very late activation protein 5, alpha subunit
  • VLA-5 alpha
  • VLA-5

Background

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha V chain. Alpha chain V undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGA5
Entrez
Uniprot