Integrin alpha 4/CD49d Antibody (R1-2) [Biotin]

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Flow Cytometry: Integrin alpha 4/CD49d Antibody (R1-2) [Biotin] [NBP1-43634] - Surface staining of mouse splenocytes with Anti-Mouse CD49d (Integrin alpha 4) PE. Appropriate isotype controls were used (open histogram). ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
R1-2
Clonality
Monoclonal
Host
Rat
Concentration
0.5 mg/ml

Order Details

Integrin alpha 4/CD49d Antibody (R1-2) [Biotin] Summary

Immunogen
Lymphoma cell line TK1
Specificity
NB100-65371 recognizes murine CD49d, an integrin which is also known as very late antigen 4 (VLA-4). CD49d forms a heterodimer at the cell surface with CD29, and is involved in cell-cell and cell-extracellular matrix interactions. Clone R1-2 recognizes an epitope within residues 195-268 of CD49d, designated as B1. The clone has also been reported to inhibit the adhesion of murine lymphocytes to Peyer's patch HEV.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
ITGA4
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
Biotin
Format
Biotin (A=N/A, E=N/A)
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000

Reactivity Notes

Reacts with Mouse.

Alternate Names for Integrin alpha 4/CD49d Antibody (R1-2) [Biotin]

  • 269C wild type
  • CD49 antigen-like family member D
  • CD49d antigen
  • CD49d
  • CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor
  • IA4
  • Integrin alpha 4
  • integrin alpha-4 subunit
  • integrin alpha-4
  • Integrin alpha-IV
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
  • ITGA4
  • MGC90518
  • very late activation protein 4 receptor, alpha 4 subunit
  • VLA-4 subunit alpha
  • VLA-4

Background

The R1-2 monoclonal antibody reacts with mouse CD49d, the 150 kDa integrin alpha4 subunit. The complex of CD49d non-covalently associated with integrin beta1 (CD29), also known as VLA-4, is a receptor for fibronectin and VCAM-1 (CD106). This complex is expressed by thymocytes, peripheral lymphocytes, monocytes and eosinophils. CD49d also associates with integrin b7 and binds to the Mucosal vascular ADdressin (MAdCAM-1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ITGA4
Entrez

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