Integrin alpha 3/CD49c Antibody (VM-2)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-64602
    • Availability
      Product Discontinued

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Integrin alpha 3/CD49c Antibody (VM-2) Summary

Immunogen
Skin cells from psoriatic plaques
Specificity
Recognizes the human CD49c cell surface antigen, also known as the alpha-3 integrin and as VLA-3. CD49c is expressed by B lymphocytes, within normal skin and upon kidney glomeruli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGA3
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:50-1:100
Application Notes
The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. The use of acetone fixation for frozen sections is recommended.
Positive Control
Integrin alpha 3/CD49c Lysate (NBL1-12063)

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tissue culture supernatant
Preservative
15mM Sodium Azide
Concentration
LYOPH
Purity
Tissue culture supernatant
Reconstitution Instructions
Reconstitute to desired concentration.

Alternate Names for Integrin alpha 3/CD49c Antibody (VM-2)

  • antigen identified by monoclonal J143
  • CD49 antigen-like family member C
  • CD49c antigen
  • CD49c
  • FLJ34631
  • FLJ34704
  • FRP-2
  • Galactoprotein B3
  • GAP-B3
  • GAPB3CD49C
  • Integrin alpha 3
  • integrin alpha-3
  • integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
  • ITGA3
  • MSK18
  • VCA-2
  • very late activation protein 3 receptor, alpha-3 subunit
  • VL3A
  • VLA-3 subunit alpha
  • VLA3a

Background

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 (VLA3), very common antigen 2 (VCA2), extracellular matrix receptor 1 (ECMR1), and galactoprotein b3 (GAPB3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional Integrin alpha 3/CD49c Products

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Bioinformatics

Gene Symbol ITGA3
Entrez
Uniprot