Integrin alpha 3/CD49c Antibody (ASC-1) - BSA Free

Flow (Cell Surface): Integrin alpha 3/CD49c Antibody (ASC-1) [NBP2-62200] - Surface staining of HeLa cells with anti-CD49c (ASC-1) PE.

Flow (Cell Surface): Integrin alpha 3/CD49c Antibody (ASC-1) [NBP2-62200] - Surface staining of HeLa cells with anti-CD49c (ASC-1) purified, GAM-APC.

• Reactivity: Hu
• Applications: WB, Flow, IHC, IP
• Clone: ASC-1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

Integrin alpha 3/CD49c Antibody (ASC-1) - BSA Free Summary

• Additional Information: Clone ASC-1 was used by HLDA to establish CD designation.
• Immunogen: Human SSC-9 cell line (squamous cell carcinoma)
• Specificity: The antibody HTF-14 recognizes an epitope located in the N-terminal domain of human serum transferrin, a 77 kDa single polypeptide chain glycoprotein (member of the iron binding family of proteins). It is synthesised in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1-4 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000
• Theoretical MW: 125 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for Integrin alpha 3/CD49c Antibody (ASC-1) - BSA Free

• antigen identified by monoclonal J143
• CD49 antigen-like family member C
• CD49c antigen
• CD49c
• FLJ34631
• FLJ34704
• FRP-2
• Galactoprotein B3
• GAP-B3
• GAPB3CD49C
• Integrin alpha 3
• integrin alpha-3
• integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
• ITGA3
• MSK18
• VCA-2
• very late activation protein 3 receptor, alpha-3 subunit
• VL3A
• VLA-3 subunit alpha
• VLA3a

Background

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 (VLA3), very common antigen 2 (VCA2), extracellular matrix receptor 1 (ECMR1), and galactoprotein b3 (GAPB3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 3/CD49c Antibody (NBP2-62200)(1)

Publication using NBP2-62200

• Gao L, Wang A, Chen Y et al. FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer Cell communication and signaling : CCS 2023-11-02 [PMID: 37919739] (WB)

Bioinformatics

• Gene Symbol: ITGA3