Integrin alpha 2b/CD41 Antibody (HIP2)

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Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42522
    • Availability
      Product Discontinued

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Integrin alpha 2b/CD41 Antibody (HIP2) Summary

Immunogen
The antibody reacts with the CD41b antigen.
Specificity
CD41 (GPIIb) is a calcium-depedent, noncovalently associated heterodimer and contains a heavy chain (GPIIb-alpha) and a light chain (GPIIb-beta) linked by a single disulfied bond. The HIP2 monoclonal antibody reacts with the human CD41 molecule IIb also known as platelet GPIIb. CD41 non-covalently associates with beta3 integrin (GPIIIa, CD61) and is expressed by platelet precursors and platelets (megakaryocytes). The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. The GPIIb/IIIa may be absent or strongly reduced in Glanzmann's thrombasthenia(GT).
Isotype
IgG3
Clonality
Monoclonal
Host
Mouse
Gene
ITGA2B
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
The antibody can be used for Flow Cytometry and immunohistochemistry on frozen sections.This HIP2 antibody has been tested by flow cytometric analysis of human platelets. This can be used at less than or equal to 1 mg per 100 ml blood.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Integrin alpha 2b/CD41 Antibody (HIP2)

  • CD41 antigen
  • CD41
  • CD41BHPA3
  • GP2B
  • GP2Bintegrin alpha-IIb
  • GPalpha IIb
  • GPIIb
  • GTA
  • HPA3
  • Integrin alpha 2b
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
  • ITGA2b
  • ITGAB
  • platelet fibrinogen receptor, alpha subunit
  • Platelet membrane glycoprotein IIb
  • platelet-specific antigen BAK

Background

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumour cells. This protein is identified as capable of immunoprecipitating a non-reducible alpha subunit from I125 surface labelled Human cell line extract. It is confirmed as specific to the alpha 2 subunit by relative expression of antigen on various cell lines by Flow Cytometry, and its recognition of affinity purified alpha 2 beta 1 in dot blots.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGA2B
Entrez