Integrin alpha 2b/CD41 Antibody (CRC64)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42149
    • Availability
      Product Discontinued

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Integrin alpha 2b/CD41 Antibody (CRC64) Summary

Immunogen
The antibody reacts with human platelets and megakaryocytes.
Specificity
The monoclonal antibody recognizes the intact platelet GPIIb/IIIa complex (alphaIIb­/beta3-integrin), i.e. it does not bind to dissociated GPIIb or GPIIIa. The antibody reacts with human platelets and megakaryocytes. Apparent molecular weight under reducing conditions: GPIIIa; 110 kD; GPIIb alpha chain; 125 kD, beta chain; 25 kD. The antibody does not bind to platelets from patients with Glanzmann thrombasthe­nia and does not recognize the vitronectin receptor, which contains GPIIIa as a beta subunit (cf. CD61). CRC64 (both intact antibody and F(ab')2 fragments) inhibits platelet aggregation by blocking fibrinogen binding to the glycoprotein IIb-IIIa complex.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ITGA2B
Purity
Ammonium sulfate precipitation
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
The monoclonal antibody is a useful marker for megakaryoblasts and megakaryo-bla­stic leukemias and also useful for functional studies.The antibody can be used for indirect immunofluorescence staining with analysis by cytofluoro­metry in flow cytometry or fluorescence microscopy. A platelet aggregation is blocked at the concentration of 1-5 µg/µl. See for further instructions A.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 mg antibody with PBS
Preservative
Sodium Azide
Purity
Ammonium sulfate precipitation

Alternate Names for Integrin alpha 2b/CD41 Antibody (CRC64)

  • CD41 antigen
  • CD41
  • CD41BHPA3
  • GP2B
  • GP2Bintegrin alpha-IIb
  • GPalpha IIb
  • GPIIb
  • GTA
  • HPA3
  • Integrin alpha 2b
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
  • ITGA2b
  • ITGAB
  • platelet fibrinogen receptor, alpha subunit
  • Platelet membrane glycoprotein IIb
  • platelet-specific antigen BAK

Background

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGA2B
Entrez