Integrin alpha 2/CD49b Antibody (CLB-50)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42479
    • Availability
      Product Discontinued

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Integrin alpha 2/CD49b Antibody (CLB-50) Summary

Immunogen
human T-lymphocytes.
Marker
Plasma Membrane Marker
Specificity
The monoclonal antibody is directed against the CD49b antigen, molecular weight 130, 170 kD (GP Ia or VLA-2 alpha-chain), which can form distinct complexes with either the CD29 antigen (GP IIa or VLA beta-chain), resulting in the VLA-2 (alpha-2, beta-1) complex which is expressed on human platelets. The monoclonal antibody reacts with platelets, long-term cultured T-lymphocytes and activated T-lymphocytes. In immunohistology the monoclonal antibody reacts with thymocytes, epithelial cells of a variety of tissues, peripheral nerves, fibroblasts, osteoclasts, glomerular mesang­ium and most non-haemopoietic adherent cell lines. Platelet VLA-2 functions as a collagen and laminin receptor. Platelet adhesion is inhibited by this antibody.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGA2
Purity
Ammonium sulfate precipitation
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
Functional studies on VLA-2. Detection of human alloantibodies (anti-Bra,b) against VLA-2 (MAIPA assay).The antibody is useful for indirect immunofluorescence staining with analysis by cytofluoro­metry or fluorescence microscopy, immunoblotting, immunohistology and MAIPA assay.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
No Preservative
Purity
Ammonium sulfate precipitation

Alternate Names for Integrin alpha 2/CD49b Antibody (CLB-50)

  • alpha-2 subunit
  • CD49b antigen
  • CD49b
  • Integrin alpha 2
  • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
  • ITGA2
  • VLA 2
  • VLA-2 alpha

Background

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumors. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGA2
Entrez