Integrin alpha 1/CD49a Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42588
    • Availability
      Product Discontinued

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Integrin alpha 1/CD49a Antibody Summary

Immunogen
A peptide at the C-terminus of ITGA1 of human origin, identical to the related mouse equence.
Clonality
Polyclonal
Host
Rabbit
Gene
ITGA1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1-2ug/ml
  • Immunoprecipitation
Application Notes
Immunohistochemistry-Paraffin: boiling sections is required.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 mg DiSodium Phosphate, 0.9 mg NaCl and 50% Glycerol
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute with distilled water.

Alternate Names for Integrin alpha 1/CD49a Antibody

  • CD49 antigen-like family member A
  • CD49a antigen
  • CD49a
  • Integrin alpha 1
  • integrin, alpha 1
  • ITGA1
  • Laminin and collagen receptor
  • very late activation protein 1
  • VLA-1
  • VLA1integrin alpha-1

Background

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellular adhesion to laminin and collagen.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Integrin alpha 1/CD49a Antibody (NBP1-42588). (Showing 1 - 1 of 1 FAQ).

  1. Today I received an inquiry from a customer who purchased #NBP1-42588, Integrin alpha 1 Antibody. According to the datasheet, this antibody was lyophilized but reconstitution method was not written. So the customer would like to know the reconstitution buffer.
    • NBP1-42588 should be reconstituted with ddH20 to a desired concentration. The product is provided in 100ug, so adding 100uL of water would give a concentration of 1mg/ml.

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Bioinformatics

Gene Symbol ITGA1
Entrez
Uniprot