ING1 Antibody

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Western Blot: ING1 Antibody [NB600-908] - Analysis is shown using Affinity Purified anti-p33 ING1 antibody to detect over expressed Human ING1 present in cell nuclear extracts. This western blot shows reactivity with ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated

Order Details

ING1 Antibody Summary

Immunogen
Synthetic peptide: ADKPNSKRSRRQC, corresponding to amino acids 285-296 of Human ING 1.
Localization
Nuclear
Specificity
Reactivity occurs against human p33 ING1 protein and is 100% homologous to all four isoforms (A, B, C, and D) on record for this protein. Cross reactivity with p33 ING1 protein from mouse and rat sources is expected based on high homology (one amino acid change in sequence) by BLAST. Reactivity with p33 ING1 proteins from other sources is not known.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ING1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • ELISA 1:4000-1:14000
Application Notes
This affinity-purified antibody has been tested for use in ELISA and western blotting using over expressed cell lysates. Expect a band approximately 47 kDa, 33 kDa or 24 kDa in size corresponding - variants of ING1 by western blotting in the appropriate cell lysate or extract. Specific conditions for other applications should be optimized by the end user.
Control Peptide
ING1 Protein (NBP1-96943)

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for ING1 Antibody

  • growth inhibitor ING1
  • growth inhibitory protein ING1
  • ING1
  • inhibitor of growth family, member 1
  • inhibitor of growth protein 1
  • p24ING1c
  • p33
  • p33ING1
  • p33ING1b
  • p47
  • p47ING1a
  • tumor suppressor ING1

Background

p33 ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53-signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. The accession number listed below is for variant (4) that encodes the longest isoform (D). Other synonyms for p33 ING1 include p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a, growth inhibitor ING1, inhibitor of growth 1, tumor suppressor ING1 and growth inhibitory protein ING1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Blogs on ING1.

Understanding the Reasons for Histone H3 K4 Trimethylation (H3K4Me3)
Epigenetic mechanisms allow distinction between the active and inactive compartments of the genome, allowing proper cell lineage and embryogenesis. The trimethylation of Histone 3 at lysine 4 (H3K4Me3) is a common epigenetic histone modification that...  Read full blog post.

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Bioinformatics

Gene Symbol ING1
Entrez