IL18R1 Antibody (H44) [Biotin]

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Flow Cytometry: IL18R1 Antibody (H44) [Biotin] [NB100-77940] - Human peripheral blood lymphocytes stained with biotinylated H44, followed by Sav-PE

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-77940
    • Availability
      Product Discontinued

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IL18R1 Antibody (H44) [Biotin] Summary

Immunogen
Human NK cell line NK0 constitutively expressing IL-18 receptors
Specificity
IL18R1 (H44)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
IL18R1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application.
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for IL18R1 Antibody (H44) [Biotin]

  • CD218 antigen-like family member A
  • CD218a antigen
  • CD218a
  • CDw218a
  • cytokine receptor
  • IL-18R1
  • IL-18R-1
  • IL1R-rp
  • IL1RRPIL1 receptor-related protein
  • IL-1RrpIL18RA
  • interleukin 18 receptor 1
  • interleukin-18 receptor 1

Background

IL18R1 is composed of an alpha and a beta subunit that combine to form a high affinity receptor for IL-18. IL18R1 alpha chain, also known as CDw218a, is a 75-80 kD type I transmembrane protein. It is expressed on NK cells, neutrophils, endothelial cells, and subsets of T and B cells. The expression of CDw218a on lymphocytes is upregulated after activation. The interaction of IL-18 and IL-18 receptor has been reported to be implicated in promotion of Th1 cytokine production and atherogenesis. The H44 antibody is specific for IL-18 receptor alpha chain and has been reported to block IL-18 binding to the receptor and to be useful for the identification of IL18R1 by flow cytometry and IHC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL18R1