IL-9 Partial Recombinant Protein Summary
A partial protein corresponding to IL9.
Insect-derived amino acids Met1-Pro144, accession number NM_008373.
|Details of Functionality
The ED50 of this protein, as determined by TS-1 cell proliferation assay, is less than or equal to 2 ng/ml. This corresponds to a specific activity of greater than or equal to 5x10^5Units/mg.
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid, phosphate buffered saline, pH7.2
0.09% Sodium Azide
- Flow Cytometry
This protein was made to the mouse sequence.
Purity: Greater than 90%, as determined by SDS-PAGE
Alternate Names for IL-9 Partial Recombinant Protein
- Cytokine P40
- IL-9homolog of mouse T cell and mast cell growth factor 40
- interleukin 9
- p40 cytokine
- p40 T-cell and mast cell growth factor
- T-cell growth factor P40
Interleukin-9 (IL-9) is a 14 kDa cytokine originally named P40 and identified by its proliferative effects on T cell populations. The receptor, which is a heterodimer of the gamma chain portion of the IL-2 receptor and the IL-9R chain, activates Jak/STAT signaling pathways upon binding its ligand. Since the discovery of IL-9, numerous other functions have been observed. It induces Th17 and Treg differentiation in CD4+ T cells, IgE production in B cells, and the differentiation and proliferation of mast cells. IL-9 expression was initially observed in Th2 cells, but has since been found in Th17, eosinophil, and mast cells. Th9 cells, a newly discovered subset of CD4+ T cells, are characterized by the secretion of large amounts of IL-9 and IL-10. These cells are derived from Th2 cells reprogrammed by the presence of TGFbeta, making IL-9 the probable mechanism by which TGFbeta drives Th17 and Treg differentiation. Mouse and human IL-9 share 69% sequence homology at the nucleotide level and 57% at the protein level. Although mouse IL-9 exhibits cross-species activity, human IL-9 is species-specific.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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