IL-7 R alpha/CD127 [p Tyr449] Antibody Summary
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein.
This is specific for mouse IL-7 protein phosphorylated at Y449. A BLAST analysis was used to suggest cross-reactivity with IL-7 from human and rat sources based on 100% identity with the immunizing sequence.
Immunogen affinity purified
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Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Liquid (sterile filtered): 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
0.01% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified
Expect a band approximately 55 kDa in size corresponding - phosphorylated IL-7 by western blotting in the appropriate cell lysate or extract. This phospho-specific polyclonal antibody reacts with mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide. Immunopreciptiation should be user optimized for best results.
Reacts with Human, Mouse, and Rat.
0.82 mg/mL by UV absorbance at 280 nm
Alternate Names for IL-7 R alpha/CD127 [p Tyr449] Antibody
- CD127 antigen
- IL-7 receptor subunit alpha
- IL7R alpha
- IL-7R subunit alpha
- interleukin 7 receptor alpha chain
- interleukin 7 receptor isoform H5-6
- interleukin 7 receptor
- interleukin-7 receptor subunit alpha
Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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