Recombinant Mouse IL-6 Protein

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Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43220
    • Availability
      Product Discontinued

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Recombinant Mouse IL-6 Protein Summary

Description
A partial protein corresponding to IL6.
Preparation
Method
E. coli expressed amino acids Phe 25-Thre 211 of mature mouse IL-6 (accession # MMINTL6).
Details of Functionality
The ED50 measured in a B9 proliferation assay is typically less than 0.01 ng/ml, corresponding to a specific activity of greater than 1x10^8 Units/mg.
Protein/Peptide Type
Partial Recombinant Protein
Gene
IL6
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Application Notes
This recombinant mouse IL-6 has been tested by sandwich ELISA using the mouse IL-6 antibody pair (MP5-20F3/MP5-32C11) and in bioassays using the mouse cell line B9 (Current Protocols in Immunology).

Reactivity Notes

This protein was made to the mouse sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile 40% acetonitrile, 0.1% trifluoroacetic acid with 0.5% BSA. 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 98%, as determined by SDS-PAGE

Alternate Names for Recombinant Mouse IL-6 Protein

  • B cell stimulatory factor-2
  • B-cell differentiation factor
  • BSF-2
  • BSF2CTL differentiation factor
  • CDF
  • HGFHSFIFNB2Hybridoma growth factor
  • IFN-beta-2
  • IL6
  • IL-6
  • IL-6B-cell stimulatory factor 2
  • Interferon beta-2
  • interleukin 6 (interferon, beta 2)
  • interleukin BSF-2
  • interleukin-6
  • MGI-2A

Background

Mouse IL-6 (also known as B Cell Stimulating Factor, BCSF, and BSF-2) is a ~21-28 kDa factor produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. This pleiotrophic cytokine influences the antigen-specific immune response, inflammatory response, and the development of neurons, and is a major mediator of the acute phase reaction.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Product General Protocols

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FAQs for IL-6 Protein (NBP1-43220). (Showing 1 - 1 of 1 FAQ).

  1. I was wondering if you know of any blocking antibodies against IL-6 or VEGF-C that can be used in cell culture to quench these cytokines?
    • We have no antibodies that are currently known to show blocking antibodies to VEGF-C. Please see this link to our IL-6 antibodies with blocking/neutralizing activity can be found at this link.

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Bioinformatics

Gene Symbol IL6
Entrez