IL-4 R alpha Antibody (49/20) Summary
Sf 21-derived, recombinant human interleukin 4 receptor, extracellular domain.
NB100-65838 is specific for human interleukin 4 receptor, the transmembrane ligand-binding subunit of the heterodimeric IL-4 receptor complex. IL-4 R is expressed by B cells, T cells, monocytes and macrophages. NB100-65838 blocks human cell surface IL-4 receptor mediated bioactivities induced by IL-4 or IL-13. An ND50 was observed at approximately 5-20 ng/ml in the presence of 0.2 ng/ml of IL-4 using the factor dependant human erythroleukemic cell line, TF-1.
Protein A purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, 10% Trehalose
0.09% Sodium Azide
Protein A purified
Immunohistochemistry-Paraffin, Western Blot, ELISA, Flow Cytometry and Functional In WB will detect human IL-4 R under non-reducing conditions.
Alternate Names for IL-4 R alpha Antibody (49/20)
- CD124 antigen
- IL-4 receptor subunit alpha
- IL4R alpha
- IL-4R subunit alpha
- interleukin 4 receptor
- interleukin-4 receptor alpha chain
- interleukin-4 receptor subunit alpha
IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naive CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Applications: WB, ICC
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Applications: WB, ICC/IF, IHC, IHC-P
Applications: WB, Flow, IHC, Neut
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
Applications: WB, Simple Western, Flow, IHC, Block
Species: Hu, Mu
Applications: ELISA(Cap), ELISA(Cap), ELISA(Det), ELISA(Det), Neut, ELISA(Sta), ELISA(Sta)
Applications: WB, IHC, IHC-P
Applications: WB, ELISA, Flow, IHC, IHC-P
Publications for IL-4 R alpha Antibody (NB100-65838) (0)
There are no publications for IL-4 R alpha Antibody (NB100-65838).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for IL-4 R alpha Antibody (NB100-65838) (0)
There are no reviews for IL-4 R alpha Antibody (NB100-65838).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for IL-4 R alpha Antibody (NB100-65838) (0)
Additional IL-4 R alpha Antibody (49/20) Products
Related Products by Gene
Bioinformatics Tool for IL-4 R alpha Antibody (NB100-65838)
Discover related pathways, diseases and genes to IL-4 R alpha Antibody (NB100-65838). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on IL-4 R alpha