Recombinant Mouse IL-4 Protein Summary
A recombinant protein corresponding to 120 amino acids of Mouse IL-4
|Details of Functionality
Biological Activity: The ED50 determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is <.2.0 ng/ml, corresponding to a specific activity of >5 x 10^5 units/mg.
Results: <.2.0 ng/ml
| Protein/Peptide Type
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Reconstitute with water to a final concentration of 0.1 - 1.0 mg/ml.
After reconstituted, dilute further with other aqueous solutions.
Alternate Names for Recombinant Mouse IL-4 Protein
- B cell growth factor 1
- B-cell stimulatory factor 1
- IL-4B_cell stimulatory factor 1
- interleukin 4
- Lymphocyte stimulatory factor 1
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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