Recombinant Mouse IL-33 Protein Summary
A partial protein corresponding to IL33.
E. coli expressed protein consisting of amino acids Ser 109-Ile 266 of mature mouse IL-33 (accession # AK075849).
|Details of Functionality
This recombinant mouse IL-33 has been tested by bioassays using the cell line D10.G4.1. The ED50 measured in the D10.G4.1 proliferation assay is typically less than 0.1 ng/ml, corresponding to a specific activity of greater than 1x10^7 Units/mg.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
This protein was made to the mouse sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM Phosphate, 150 mM NaCl, 2 mM DTT, pH 7.2 (PBS with DTT) with 1.0% BSA. 0.22 um filtered.
0.09% Sodium Azide
Purity: Greater than 97%, as determined by SDS-PAGE
Alternate Names for Recombinant Mouse IL-33 Protein
- C9orf26chromosome 9 open reading frame 26 (NF-HEV)
- DVS27-related protein
- interleukin 33
- Interleukin-1 family member 11
- Nuclear factor from high endothelial venules
Mouse IL-33, also called NF-HEV and DVS 27, is a 30 kDa proinflammatory cytokine produced by endothelial and epithelial cells. IL-33 is released during necrotic cell death but was first found in the nucleus of endothelial cells. This dual pattern of expression is reminiscent of quotalarminsquot also known as endogeneous danger signals. Other known alarmins are IL-1alpha and HMGB1. IL-33 has been identified as the ligand for ST2 (a member of the Il-1 receptor family). ST2 is stably expressed on mast cells and T(h)2 effector T cells and is functionally associated with T(h)2-mediated inflammation. Although IL-33 was initially reported to be processed by Caspase-1, recent data indicate that Caspase-3 or -7 are capable of processing IL-33 at more physiologic concentrations. IL-33 plays an immune regulatory role by inducing IL-5 and IL-13 in vitro and in vivo and activating basophils, eosinophils and mast cells. In addition to its role in proimflammation, it may also decrease inflammation through interactions with IL-1 thereby blocking its effect. Mouse IL-33 share 55% amino acid sequence identity with human and 90% with rat.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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