Recombinant Human IL-33 Protein Summary
A partial protein corresponding to IL33.
E. coli expressed protein consisting of amino acids Ser 112-Thr 270 of mature human IL-33 (accession # NM-033439).
|Details of Functionality
This recombinant human IL-33 has been tested by bioassays using the cell line D10.G4.1. The ED50 measured in the D10.G4.1 proliferation assay is typically less than 1 ng/ml, corresponding to a specific activity of greater than 1x10^6 Units/mg.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
This protein was made to the human sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM sodium phosphate, pH 7.2, 150 mM NaCl, with 1% BSA. 0.22 um filtered.
0.09% Sodium Azide
Purity: Greater than 98%, as determined by SDS-PAGE
Alternate Names for Recombinant Human IL-33 Protein
- C9orf26chromosome 9 open reading frame 26 (NF-HEV)
- DVS27-related protein
- interleukin 33
- Interleukin-1 family member 11
- Nuclear factor from high endothelial venules
Human IL-33, also called NF-HEV and DVS 27, is a 30 kDa proinflammatory cytokine produced by endothelial and epithelial cells. IL-33 is released during necrotic cell death but was first found in the nucleus of endothelial cells. This dual pattern of expression is reminiscent of quotalarminsquot also known as endogeneous danger signals. Other known alarmins are IL-1alpha and HMGB1. IL-33 has been identified as the ligand for ST2 (a member of the Il-1 receptor family). ST2 is stably expressed on mast cells and T(h)2 effector T cells and is functionally associated with T(h)2-mediated inflammation. Although IL-33 was initially reported to be processed by Caspase-1, recent data indicate that Caspase-3 or -7 are capable of processing IL-33 at more physiologic concentrations. IL-33 plays an immune regulatory role by inducing IL-5 and IL-13 in vitro and in vivo and activating basophils, eosinophils and mast cells. In addition to its role in proimflammation, it may also decrease inflammation through interactions with IL-1 thereby blocking its effect. Human IL-33 shares 55% amino acid sequence identity with mouse.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
Customers Who Viewed This Item Also Viewed...
Applications: WB, Simple Western, Flow, CyTOF-ready, Neut
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Applications: WB, ICC, Neut
Applications: WB, IHC, IHC-P
Applications: WB, Flow, CyTOF-ready
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-P
Applications: WB, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
Species: Hu, Mu, Rt, Bv, Ca, Ch, Xp
Publications for IL-33 Protein (NBP1-43193) (0)
There are no publications for IL-33 Protein (NBP1-43193).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for IL-33 Protein (NBP1-43193) (0)
There are no reviews for IL-33 Protein (NBP1-43193).
By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
- Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
- Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
- 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for IL-33 Protein (NBP1-43193) (0)
Additional IL-33 Products
Bioinformatics Tool for IL-33 Protein (NBP1-43193)
Discover related pathways, diseases and genes to IL-33 Protein (NBP1-43193). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on IL-33.