IL-33 Partial Recombinant Protein Summary
A partial protein corresponding to IL33.
E. coli expressed protein consisting of amino acids Ser 112-Thr 270 of mature human IL-33 (accession # NM-033439).
|Details of Functionality
This recombinant human IL-33 has been tested by bioassays using the cell line D10.G4.1. The ED50 measured in the D10.G4.1 proliferation assay is typically less than 1 ng/ml, corresponding to a specific activity of greater than 1x10^6 Units/mg.
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM sodium phosphate, pH 7.2, 150 mM NaCl, with 1% BSA. 0.22 um filtered.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This protein was made to the human sequence.
Purity: Greater than 98%, as determined by SDS-PAGE
Alternate Names for IL-33 Partial Recombinant Protein
- C9orf26chromosome 9 open reading frame 26 (NF-HEV)
- DVS27-related protein
- interleukin 33
- Interleukin-1 family member 11
- Nuclear factor from high endothelial venules
Human IL-33, also called NF-HEV and DVS 27, is a 30 kDa proinflammatory cytokine produced by endothelial and epithelial cells. IL-33 is released during necrotic cell death but was first found in the nucleus of endothelial cells. This dual pattern of expression is reminiscent of quotalarminsquot also known as endogeneous danger signals. Other known alarmins are IL-1alpha and HMGB1. IL-33 has been identified as the ligand for ST2 (a member of the Il-1 receptor family). ST2 is stably expressed on mast cells and T(h)2 effector T cells and is functionally associated with T(h)2-mediated inflammation. Although IL-33 was initially reported to be processed by Caspase-1, recent data indicate that Caspase-3 or -7 are capable of processing IL-33 at more physiologic concentrations. IL-33 plays an immune regulatory role by inducing IL-5 and IL-13 in vitro and in vivo and activating basophils, eosinophils and mast cells. In addition to its role in proimflammation, it may also decrease inflammation through interactions with IL-1 thereby blocking its effect. Human IL-33 shares 55% amino acid sequence identity with mouse.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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