IL-33 Partial Recombinant Protein


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Product Details

Reactivity MuSpecies Glossary
Applications ELISA, IA
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

IL-33 Partial Recombinant Protein Summary

A partial protein corresponding to IL33.
E. coli expressed protein consisting of amino acids Ser 109-Ile 266 of mature mouse IL-33 (accession # AK075849).
Details of Functionality
Measured by D10.G4.1 cell proliferation assay. The ED50 is 0.03 ng/ml, corresponding to a specific activity of 3.0 x 107 Units/mg.
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Packaging, Storage & Formulations

Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM Phosphate, 150 mM NaCl, 2 mM DTT, pH 7.2 (PBS with DTT). 0.22 um filtered.
0.09% Sodium Azide


  • Immunoassay

Reactivity Notes

This protein was made to the mouse sequence.


Purity: Greater than 97%, as determined by SDS-PAGE

Alternate Names for IL-33 Partial Recombinant Protein

  • C9orf26
  • C9orf26chromosome 9 open reading frame 26 (NF-HEV)
  • DKFZp586H0523
  • DVS27
  • DVS27-related protein
  • IL1F11
  • IL-1F11
  • IL33
  • IL-33
  • interleukin 33
  • Interleukin-1 family member 11
  • interleukin-33
  • NF-HEV
  • Nuclear factor from high endothelial venules
  • RP11-575C20.2


Mouse IL-33, also called NF-HEV and DVS 27, is a 30 kDa proinflammatory cytokine produced by endothelial and epithelial cells. IL-33 is released during necrotic cell death but was first found in the nucleus of endothelial cells. This dual pattern of expression is reminiscent of quotalarminsquot also known as endogeneous danger signals. Other known alarmins are IL-1alpha and HMGB1. IL-33 has been identified as the ligand for ST2 (a member of the Il-1 receptor family). ST2 is stably expressed on mast cells and T(h)2 effector T cells and is functionally associated with T(h)2-mediated inflammation. Although IL-33 was initially reported to be processed by Caspase-1, recent data indicate that Caspase-3 or -7 are capable of processing IL-33 at more physiologic concentrations. IL-33 plays an immune regulatory role by inducing IL-5 and IL-13 in vitro and in vivo and activating basophils, eosinophils and mast cells. In addition to its role in proimflammation, it may also decrease inflammation through interactions with IL-1 thereby blocking its effect. Mouse IL-33 share 55% amino acid sequence identity with human and 90% with rat.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Blogs on IL-33.

Interleukin 33 (IL-33) - A dual function cytokine
IL-33 is a member of the interleukin family of cytokines that regulates a wide variety of cellular functions. Its receptor is ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and the IL-1R accessory...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol IL33

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