Recombinant IL-31 Protein Summary
A partial protein corresponding to IL31.
E. coli-expressed protein consisting of amino acids Thr24-Cys163 of mature mouse IL-31 (accession # XM_132344).
|Details of Functionality
Testing in progress.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Currently there is no reliable bioassay available for recombinant mouse IL-31.
This protein was made to the human sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid, 0.1 M Glycine, pH 3.0 with 1% BSA. 0.22 um filtered.
0.09% Sodium Azide
Purity: Greater than 98% as determined by SDS-PAGE
Alternate Names for Recombinant IL-31 Protein
- interleukin 31
Interleukin-31 (IL-31) is a member of the gp130/IL-6 family of cytokines that is produced predominantly, but not exclusively, by activated Th2 cells. It binds to a heterodimeric receptor complex consisting of IL-31RA (GPL, GLM-R), a gp130-like molecule, and oncostatin M receptor (OSMR). This receptor complex is expressed constitutively on keratinocytes and epithelial cells and can be upregulated on monocytes by IFN-gamma or LPS. IL-31 signaling activates the Jak/STAT signaling pathway, including STAT1, STAT3, and STAT5, as well as the PI3 kinase/AKT and MAP kinase pathways. Mouse IL-31 shares 31% amino acid identity with human IL-31 but it does not bind to the human IL-31 receptor.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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