Recombinant IL-31 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43168
    • Availability
      Product Discontinued

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Recombinant IL-31 Protein Summary

Description
A partial protein corresponding to IL31.
Preparation
Method
E. coli-expressed protein consisting of amino acids Thr24-Cys163 of mature mouse IL-31 (accession # XM_132344).
Details of Functionality
Testing in progress.
Protein/Peptide Type
Partial Recombinant Protein
Gene
IL31
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Application Notes
Currently there is no reliable bioassay available for recombinant mouse IL-31.

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid, 0.1 M Glycine, pH 3.0 with 1% BSA. 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 98% as determined by SDS-PAGE

Alternate Names for Recombinant IL-31 Protein

  • IL31
  • IL-31
  • IL-31interleukin-31
  • interleukin 31

Background

Interleukin-31 (IL-31) is a member of the gp130/IL-6 family of cytokines that is produced predominantly, but not exclusively, by activated Th2 cells. It binds to a heterodimeric receptor complex consisting of IL-31RA (GPL, GLM-R), a gp130-like molecule, and oncostatin M receptor (OSMR). This receptor complex is expressed constitutively on keratinocytes and epithelial cells and can be upregulated on monocytes by IFN-gamma or LPS. IL-31 signaling activates the Jak/STAT signaling pathway, including STAT1, STAT3, and STAT5, as well as the PI3 kinase/AKT and MAP kinase pathways. Mouse IL-31 shares 31% amino acid identity with human IL-31 but it does not bind to the human IL-31 receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol IL31
Entrez