Recombinant Human IL-31 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42906
    • Availability
      Product Discontinued

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Recombinant Human IL-31 Protein Summary

Description
A partial protein corresponding to IL31.
Preparation
Method
E. coli expressed protein consisting of amino acids Ser 24-Thr 164 of mature human IL-31 (accession # NM_001014336).
Details of Functionality
Measured by induction of STAT3 activation in U-87 cells. 5 ng/mL of rhIL-31 can effectively induce STAT3 activation.
Protein/Peptide Type
Partial Recombinant Protein
Gene
IL31
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Application Notes
This recombinant human IL-31 has been tested in bioassays using the cell line U-87.

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid; 0.1M Glycine, pH 3.0. 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 97%, as determined by SDS-PAGE

Alternate Names for Recombinant Human IL-31 Protein

  • IL31
  • IL-31
  • IL-31interleukin-31
  • interleukin 31

Background

Human Interleukin-31 (IL-31) is a T-cell derived cytokine. The human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% amino acid sequence identity in the mature region. IL-31 is mainly associated with activated T cells and preferentially expressed by Th2 rather than Th1 cells. IL-31 signals via a heterodimeric receptor complex composed of a 120 kDa, gp130-like molecule termed IL-31RA (also GPL and GLM-R) and a 180 kDa oncostatin M receptor (OSM Rb). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 signaling has been shown to involve the Jak/STAT pathway, the PI3 kinase/AKT cascade, and MAP kinase pathway. The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN-g on monocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol IL31
Entrez