IL-3 R alpha/CD123 Antibody (151231) [Alexa Fluor® 350] Summary
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL‑3 R alpha /CD123
Accession # P26952
Detects mouse IL‑3 R alpha /CD123 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human IL-3 R alpha and recombinant mouse IL-3 R beta is observed.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for IL-3 R alpha/CD123 Antibody (151231) [Alexa Fluor® 350]
- CD123 antigen
- IL-3 R alpha
- IL-3 receptor subunit alpha
- IL3R alpha
- IL-3R subunit alpha
- interleukin 3 receptor, alpha (low affinity)
- interleukin-3 receptor subunit alpha
Interleukin 3 (IL-3) is a pleiotropic cytokine produced primarily by activated T cells or mast cells. IL-3 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage-committed cells. The biological effects of IL-3 on the various cell types are mediated by the binding of IL-3 to specific cell surface receptor complexes. The functional high-affinity IL-3 receptor is a heterodimer consisting of a ligand binding alpha subunit and the beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit is required for the high-affinity binding of IL-3 to the heterodimeric receptor complex. The beta subunit has also been found to be a component of the high-affinity receptor complex for IL-5 and GM-CSF and is also referred to as the beta common ( beta c) chain. In the mouse, there are two IL-3 R beta proteins. The first identified mouse IL-3 R beta was also called AIC2A and binds IL-3 with low affinity (1). The second mIL-3 R beta was referred to as AIC2B (2). AIC2B doesn’t bind IL-3 and is the homolog of the human IL-3 R beta. AIC2A was found to be the result of a gene duplication event. The mouse IL-3 R alpha, also called SUT-1, will form complexes with either mouse IL-3 R beta protein (3). Both the alpha and the beta subunits are members of the cytokine receptor superfamily.
- Itoh, N. et al. (1990) Science 247:324.
- Gorman, D.M. et al. (1990) Proc. Natl. Acad. Sci. USA 87:5459.
- Hara, T. and A. Miyajima (1992) EMBO J. 11:1875.
- Schrader, J.W. (2001) Cytokine Reference, Oppenheim, J.J. and M. Feldmann, eds, Academic Press, New York, p. 1899.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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