IL-27 Antibody



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Product Discontinued
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IL-27 Antibody Summary

Amino acids 95-123 of human IL-27 protein was used as the immunogen.
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
100 ul of crude rabbit sera with 50% glycerol
0.025% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.

Reactivity Notes

Cow, Mouse, Rat
The amino acid sequence used as immunogen is 100% identical in human and chimpanzee, 84% identical in dog, 81% identical in cow, 76% identical in mouse and rat.


IL-27 is a 243 aa, novel heterodimeric cytokine belonging to the IL-6/IL-12 family and produced by activated antigen-presenting cells. It is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) and p28. Recent reports suggest that IL-27 is a potent inhibitor of HIV-1 replication in PBMCs, CD4 (+) T cells and macrophages. It has antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities. It is also responsible for early regulation of Th1 adaptive immune response. It strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4 (+) T cells and drives rapid clonal expansion of naive but not memory CD4 (+) T cells through the cytokine receptor WSX-1/TCCR.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol IL27

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