Recombinant Mouse IL-2 Protein Summary
A partial protein corresponding to IL2.
E. coli expressed amino acids Ala 21-Gln 169 of mouse IL-2 (accession # MMIL04).
|Details of Functionality
ED50 measured in a CTLL-2 proliferation assay is typically 100 pg/ml, corresponding to a specific activity of (1 x 10^7U/mg).
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
This reagent has been tested by sandwich ELISA using anti-mouse IL-2 antibody pair (JES6-1A12/JES6-5H4).
This protein was made to the mouse sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 5 mM citric acid, 5 mM NaHPO4, 0.4 M NaCl, pH 4.0, 1 mM DTT, with no carriers. 0.22 uM filtered.
Purity: Greater than 98%, as determined by SDS-PAGE
Alternate Names for Recombinant Mouse IL-2 Protein
- interleukin 2
- involved in regulation of T-cell clonal expansion
- T cell growth factor
- T-cell growth factor
Mouse IL-2 (also known as TCGF) is an ~17 kDa factor produced mainly by activated CD4+ T cells. IL-2 induces cell cycle progression of resting cells in an antigen non-specific manner and allows clonal expansion of activated T cells. IL-2 also acts on activated B cells, monocytes, NK cells, LAK cells, and on oligodendroglial cells in vitro. In addition, IL-2 plays a role in hematopoiesis, tumor surveillance and anti-inflammatory reactions, and hence is a central regulator of the immune response. Non-glycosylated IL-2 is biologically active.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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