Recombinant Human IL-2 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43226
    • Availability
      Product Discontinued

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Recombinant Human IL-2 Protein Summary

Description
E. coli-expressed amino acids Ala 21-Thr 153, Accession #: NM_000586.

Source: E. coli

Details of Functionality
Measured by mouse CTLL2 cell proliferation assay. The ED50 is 0.1 ng/ml, corresponding to a specific activity of 1.0 x 10E7 Units/mg.
Source
E. coli
Protein/Peptide Type
Partial Recombinant Protein
Gene
IL2
Purity
>95% pure by SDS-PAGE
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Applications/Dilutions

Application Notes
This recombinant human IL-2 has been tested by ELISA using the MQ1-17H12/rabbit polyclonal antibody pair and in bioassays using mouse cytotoxic T cell line CTLL-2. The ED50 measured in a CTLL-2 proliferation assay is typically 100 pg/ml, corresponding to a specific activity of (1 x 107 U/mg).
Theoretical MW
17.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
40mM Acetate, 0.2M NaCl, pH 5 and 1.0% BSA as a carrier. 0.22 uM filtered.
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human IL-2 Protein

  • aldesleukin
  • IL2
  • IL-2
  • IL-2lymphokine
  • interleukin 2
  • interleukin-2
  • involved in regulation of T-cell clonal expansion
  • T cell growth factor
  • T-cell growth factor
  • TCGF

Background

Human IL-2 (also known as TCGF) is a ~15 kDa factor produced mainly by activated CD4+ T cells. IL-2 induces cell cycle progression of resting cells in an antigen non-specific manner and allows clonal expansion of activated T cells. IL-2 also acts on activated B cells, monocytes, NK, LAK cells, and on oligodendroglial cells in vitro. In addition, IL-2 plays a role in hematopoiesis, tumor surveillance and anti-inflammatory reactions and hence is a central regulator of the immune response. Non-glycosylated IL-2 is biologically active.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol IL2
Entrez