IL-2 Antibody (JES6-1A12)

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Western Blot: IL-2 Antibody (JES6-1A12) [NB100-63299] - Analysis of mouse IL-2 recombinant protein probed with RAT ANTI MOUSE INTERLEUKIN-2 (NB100-63299) followed by F(ab')2 RABBIT ANTI RAT IgG:HRP

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-63299
    • Availability
      Product Discontinued

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IL-2 Antibody (JES6-1A12) Summary

Immunogen
E. coli expressed recombinant mouse IL-2
Localization
Secreted
Specificity
NB100-63299 is specific for mouse Interleukin-2 (IL-2), Murine IL-2 is a potent lymphoid cell growth factor which primarily acts on T lymphocytes. This antibody recognizes both natural and recombinant mouse IL-2. Clone JES6-1A12 is reported to function as a neutralizing antibody.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
IL2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml-5 ug/ml
  • ELISA 1 ug/ml-4 ug/ml
  • Immunoprecipitation 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for IL-2 Antibody (JES6-1A12)

  • aldesleukin
  • IL2
  • IL-2
  • IL-2lymphokine
  • interleukin 2
  • interleukin-2
  • involved in regulation of T-cell clonal expansion
  • T cell growth factor
  • T-cell growth factor
  • TCGF

Background

Human interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL-2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics Tool for IL-2 Antibody (NB100-63299)

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Bioinformatics

Gene Symbol IL2
Entrez
Uniprot