Recombinant Human IL-1ra/IL-1F3/IL1RN Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-99441
    • Availability
      Product Discontinued

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Recombinant Human IL-1ra/IL-1F3/IL1RN Protein Summary

Description
A recombinant protein corresponding to 153 amino acids of Human IL-1ra/IL-1F3/IL1RN

Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Pro-Ser-Gly.
Preparation
Method
>98% SDS-PAGE
Details of Functionality
Biological Activity: The ED50 as determined by the dose-dependent inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ng/ml.
Results: 0.5 ng/ml
Protein/Peptide Type
Recombinant Protein
Gene
IL1RN
Purity
>90% SDS-PAGE

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
No additives.
Concentration
Lyoph
Purity
>90% SDS-PAGE
Reconstitution Instructions
Centrifuge prior to opening. Reconstitute with sterilized water to a final concentration greater than or equal to 0.1 mg/ml.

Notes

After reconstituted, dilute further with other aqueous solutions.

Alternate Names for Recombinant Human IL-1ra/IL-1F3/IL1RN Protein

  • DIRA
  • ICIL-1RA
  • IL1F3
  • IL-1F3
  • IL1ra
  • IL-1ra
  • IL-1ra3
  • IL1RN
  • IL-1RN
  • interleukin 1 receptor antagonist
  • IRAP
  • MVCD4

Background

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1RA Human Recombinant produced in E.Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton. The IL1RA is purified by proprietary chromatographic techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol IL1RN
Entrez