IL-1ra/IL-1F3/IL1RN Recombinant Protein Summary
A recombinant protein corresponding to 153 amino acids of Human IL-1ra/IL-1F3/IL1RN
Source: E. coli
Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Pro-Ser-Gly.
|Details of Functionality
The EDSO as determined by the dose-dependent inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ng/ml.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Centrifuge prior to opening. Reconstitute with sterilized water to a final concentration greater than or equal to 0.1 mg/ml.
After reconstituted, dilute further with other aqueous solutions.
Alternate Names for IL-1ra/IL-1F3/IL1RN Recombinant Protein
- interleukin 1 receptor antagonist
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1RA Human Recombinant produced in E.Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton. The IL1RA is purified by proprietary chromatographic techniques.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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