IL-18 R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin]


Human peripheral blood mononuclear cells (PBMCs) treated with 10 ng/mL Recombinant Human IL‑2 (Catalog # 202-IL) and 5 μg/mL PHA for 48 hours were stained with Mouse Anti-Human IL‑18 R alpha /IL‑1 R5 more

Product Details

Reactivity HuSpecies Glossary
Applications Flow

IL-18 R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin] Summary

Mouse myeloma cell line NS0-derived recombinant human IL‑18 R alpha /IL-1 R5
Accession # Q13478
Detects human IL-18 R alpha /IL-1 R5 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-1 RI, rhIL-1 RII, rhIL‑1 R3, rhIL-1 R4, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, rhIL-1 R9, rhSIGIRR or recombinant mouse IL-18 R alpha is observed.
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Flow Cytometry 10 uL/10^6 cells
Read Publications using
FAB840P in the following applications:

  • 6 publications

Packaging, Storage & Formulations

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied in a saline solution containing BSA and Sodium Azide.
Sodium Azide
Protein A or G purified from hybridoma culture supernatant


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-18 R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin]

  • CD218a
  • IL-1 R5
  • IL-1 Rrp
  • IL-18 R alpha
  • IL-18 R1
  • IL18R alpha
  • IL18R1
  • IL-18Ra


Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also known as IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also known as IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R alpha by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL-18 in vitro, co-expression of IL‑18 R alpha and IL‑18 R beta is required for high affinity binding and IL-18 responsiveness. Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.

  1. Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.
  2. Torigoe, K. et al. (1997) J. Biol. Chem. 272:25737.
  3. Born, T.L. et al. (1998) J. Biol. Chem. 273:29445.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Mu
Applications: WB, Flow, CyTOF-ready, Neut
Species: Hu
Species: Hu
Applications: WB, Simple Western, Flow, CyTOF-ready, Neut
Species: Hu
Species: Hu
Applications: WB, Flow, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-P
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt, Xp, Ye, Ze
Applications: ELISA

Publications for IL-18 R alpha/IL-1 R5 Antibody (FAB840P)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow.

Filter By Application
All Applications
Filter By Species
All Species
Showing Publications 1 - 6 of 6.
Publications using FAB840P Applications Species
Sundstrom P, Ahlmanner F, Akeus P, Sundquist M, Alsen S, Yrlid U, Borjesson L, Sjoling A, Gustavsson B, Wong S, Quiding-Jarbrink M Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-gamma. J Immunol, 2015;195(7):3472-81. 2015 [PMID: 26297765] (Flow,, Human) Flow Human
Uzan B, Poglio S, Gerby B, Wu C, Gross J, Armstrong F, Calvo J, Cahu X, Deswarte C, Dumont F, Passaro D, Besnard-Guerin C, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Baud V, Ghysdael J, Baleydier F, Porteu F, Pflumio F Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression. EMBO Mol Med, 2014;6(6):821-34. 2014 [PMID: 24778454] (Flow,, Human) Flow Human
Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer's disease. Cytokine, 2013;61(2):360-3. 2013 [PMID: 23201485] (Flow,, Human) Flow Human
Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, Milder M, Le Bourhis L, Soudais C, Treiner E, Lantz O Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood, 2011;117(4):1250-9. 2011 [PMID: 21084709] (Flow,, Human) Flow Human
De Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, Prakken BJ Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum., 2009;60(9):2782-93. 2009 [PMID: 19714583] (Flow,, Human) Flow Human
Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J. Immunol., 2003;170(11):5571-7. 2003 [PMID: 12759435] (Flow,, Human) Flow Human

Reviews for IL-18 R alpha/IL-1 R5 Antibody (FAB840P) (0)

There are no reviews for IL-18 R alpha/IL-1 R5 Antibody (FAB840P). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for IL-18 R alpha/IL-1 R5 Antibody (FAB840P) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Additional Array Products

Bioinformatics Tool for IL-18 R alpha/IL-1 R5 Antibody (FAB840P)

Discover related pathways, diseases and genes to IL-18 R alpha/IL-1 R5 Antibody (FAB840P). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-18 R alpha/IL-1 R5 Antibody (FAB840P)

Discover more about diseases related to IL-18 R alpha/IL-1 R5 Antibody (FAB840P).

Pathways for IL-18 R alpha/IL-1 R5 Antibody (FAB840P)

View related products by pathway.

PTMs for IL-18 R alpha/IL-1 R5 Antibody (FAB840P)

Learn more about PTMs related to IL-18 R alpha/IL-1 R5 Antibody (FAB840P).

Blogs on IL-18 R alpha/IL-1 R5

There are no specific blogs for IL-18 R alpha/IL-1 R5, but you can read our latest blog posts.

Customers Who Bought This Also Bought


Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our IL-18 R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin] and receive a gift card or discount.


Gene Symbol IL18R1