IL-13 Partial Recombinant Protein Summary
A partial protein corresponding to IL13.
E. coli expressed amino acids Ser 26-Phe 131 of mature mouse IL-13 (accession # NM_008355).
|Details of Functionality
This recombinant mouse IL-13 has been tested by bioassay using the IL-13 responsive cell line TF-1. The ED50, as determined by the dose-dependent proliferation of TF-1 cells, is ~3.8 ng/ml, corresponding to a specific activity of 2.7 x 10^5 Units/mg.
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM sodium phosphate, pH 7.2, 150 mM NaCl, with 0.5% BSA. 0.22 um filtered.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This protein was made to the mouse sequence.
Purity: Greater than 98%, as determined by SDS-PAGE
Alternate Names for IL-13 Partial Recombinant Protein
- interleukin 13
Mouse interleukin-13 (IL-13), originally designated p600, is a 11.6 kDa protein secreted by activated T helper cells, CD8+ T cells, and NK cells. IL-13 was originally identified in 1989 through differential hybridization of cDNA libraries prepared from T helper 1 and T helper 2 cells. IL-13 contains four cysteine residues, which form two intramolecular disulfide bonds. IL-13 shares many activities with IL-4 this relates to a requirement for IL-4Ralpha chain for signal transduction. The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression, and suppression of inflammatory cytokine expression. IL-13 induces CD23 expression on B cells and enhances CD72, and expression of class II MHC gene products. Mouse IL-13 does not display the activities on T cells and B cell stimulatory effects which IL-4 exhibits. Mouse IL-13 is active on human and mouse cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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