IL-12 Partial Recombinant Protein


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Product Details

Reactivity HuSpecies Glossary
Applications ELISA, IA
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

IL-12 Partial Recombinant Protein Summary

A partial protein corresponding to IL12A.
Insect cells infected with baculovirus: human p40, amino acids met 1-ser 328, (accession # NM_002187) was co-expressed with human p35, amino acids met 1-ser-253, (accession # NM_000882).
Details of Functionality
Measured by dose-dependent induction of proliferation of PHA-activated human peripheral blood mononuclear cells. This IL-12 p70 protein has been tested by bioassay, yielding an ED50 of 100 pg/ml, corresponding to a specific activity of approximately 1x10^7Units/mg.
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Packaging, Storage & Formulations

Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 20 mM NaH2PO4, pH 6.0, 0.2 M NaCl, with 1.0% BSA. 0.22 um filtered.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.


Application Notes
This recombinant human IL-12 p70 has been tested by sandwich ELISA using the human IL-12 p70 ELISA (B-T21/C8.6).

Reactivity Notes

This protein was made to the human sequence.

Alternate Names for IL-12 Partial Recombinant Protein

  • CLMF p35
  • CLMF1
  • Cytotoxic lymphocyte maturation factor 35 kDa subunit
  • IL-12 subunit p35
  • IL12
  • IL-12, subunit p35
  • IL12A
  • interleukin 12, p35
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35)
  • interleukin-12 alpha chain
  • interleukin-12 subunit alpha
  • natural killer cell stimulatory factor 1, 35 kD subunit
  • NF cell stimulatory factor chain 1
  • NK cell stimulatory factor chain 1
  • NKSF1
  • p35


Interleukin-12 (IL-12) is a heterodimeric 70 kD (p70) cytokine composed of two covalently linked, glycosylated chains, 40kD (p40) and 35-kD (p35). IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides (LPS), to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma (IFN-gamma) production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. It is now established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-gamma and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Product PDFs


Gene Symbol IL12A

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