Recombinant IL-11 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43216
    • Availability
      Product Discontinued

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Recombinant IL-11 Protein Summary

Description
A partial protein corresponding to IL11.
Preparation
Method
E. coli expressed amino acids Pro22 - Leu199 (Accession # P20809.1)
Details of Functionality
The ED50, as determined by the dose-dependent stimulation of mouse 7TD1 cell proliferation, is 1.9 ng/ml.
Protein/Peptide Type
Partial Recombinant Protein
Gene
IL11
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid, phosphate buffered saline, pH 7.2, with 1.0% BSA. 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 90%, as determined by reducing SDS-PAGE

Alternate Names for Recombinant IL-11 Protein

  • Adipogenesis inhibitory factor
  • AGIF
  • AGIFoprelvekin
  • IL11
  • IL-11
  • IL-11Oprelvekin
  • interleukin 11
  • interleukin-11

Background

Human Interleukin-11 (IL-11) belongs to the IL-6 family of cytokines and is produced by bone marrow stromal cells, fibroblasts, epithelial cells, osteoclasts and other stromal cells. IL-11 is a pleiotropic cytokine that has been shown to have broad effects on many cell types. Among its effects are stimulation of megakaryocyte maturation, regulation of osteoblast growth and differentiation, enhanced platelet production (especially after trauma or homeostatic disruption), proliferation of lymphocytes and a protective role for gut epithelial cells. Mouse and human IL-11 share about 88% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol IL11
Entrez