IL-10 R alpha Antibody Summary
Recombinant fragment corresponding to a region within amino acids 216 and 518 of IL10 Receptor alpha (Uniprot ID#Q13651)
Membrane; Single-pass type I membrane protein
Immunogen affinity purified
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Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7).
Immunogen affinity purified
suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Alternate Names for IL-10 R alpha Antibody
- CD210 antigen
- IL-10 receptor subunit alpha
- IL10R alpha
- IL-10R subunit 1
- IL10RIL-10R subunit alpha
- interleukin 10 receptor, alpha
- interleukin-10 receptor alpha chain
- Interleukin-10 receptor subunit 1
- interleukin-10 receptor subunit alpha
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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