IHPK2 Antibody

Images

 
Western Blot: IHPK2 Antibody [NBP1-00888] Extracts from A549 cells.
Western Blot: IHPK2 Antibody [NBP1-00888] - Western blot (WB) analysis of IP6K2 (L188) antibody in extracts from HUVEC or COLO or Jurkat cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-00888
    • Availability
      Product Discontinued

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IHPK2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 156-204 of Human IP6K2.
Clonality
Polyclonal
Host
Rabbit
Gene
IP6K2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of IP6K2 (L188) pAb in extracts from A549 cells.
Theoretical MW
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IHPK2 Antibody

  • EC 2.7.4.21
  • IHPK2ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
  • inositol hexakisphosphate kinase 2
  • inositol hexaphosphate kinase 2
  • InsP6 kinase 2
  • P(i)-uptake stimulator
  • pi uptake stimulator
  • PIUS

Background

The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol IP6K2
Entrez