IgM Antibody (2A6)

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Product Details

Summary
Product Discontinued
View other related IgM Primary Antibodies

Order Details


    • Catalog Number
      NB110-7090
    • Availability
      Product Discontinued

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IgM Antibody (2A6) Summary

Immunogen
IgM from human serum.
Specificity
Mu-chain of human IgM, Fc -region localized epitope.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IGHM
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Conjugation and Western Blot; can be used for passive haemagglutination. Optimal dilutions and concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for IgM Antibody (2A6)

  • AGM1
  • DKFZp686I15196
  • DKFZp686I15212
  • FLJ00385
  • IgM
  • immunoglobulin heavy constant mu
  • MGC104996
  • MGC52291
  • MU
  • VH

Background

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenstr0m's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

Additional IgM Products

Bioinformatics Tool for IgM Antibody (NB110-7090)

Discover related pathways, diseases and genes to IgM Antibody (NB110-7090). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for IgM Antibody (NB110-7090)

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Pathways for IgM Antibody (NB110-7090)

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Research Areas for IgM Antibody (NB110-7090)

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Blogs on IgM.

Understanding the Importance of Human IgG
Human IgG is a component of the immune system that protects the body from infection. It is the most abundantly found antibody isotype within the circulatory system of the human body. All antibody isotypes contain two heavy chains and two light chains...  Read full blog post.

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Bioinformatics

Gene Symbol IGHM
Entrez
Uniprot