IGFBP-1 Antibody Summary
E. coli expressed human IGF-BP1
Immunogen affinity purified
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Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
PBS, pH 7.2, containing 30% glycerol.
Immunogen affinity purified
Recombinant human IGFBP-1 can be used as a positive control.
Alternate Names for IGFBP-1 Antibody
- alpha-pregnancy-associated endometrial globulin
- amniotic fluid binding protein
- binding protein-25
- binding protein-26
- binding protein-28
- growth hormone independent-binding protein
- IGF-binding protein 1
- insulin-like growth factor binding protein 1
- insulin-like growth factor-binding protein 1
- Placental protein 12
Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner. Post translational modification of IGFBPs, including phosphorylation and proteolysis, will modify the affinities of the binding proteins for IGF and may indirectly regulate IGF actions. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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Applications: WB, ELISA(Cap), ELISA(Det), Neut, ELISA(Sta)
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Bioinformatics Tool for IGFBP-1 Antibody (NBP1-50716)
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