Recombinant Human Insulin Like Growth Factor-II is fully biologically active when compared to standards.The ED50, calculated by the dose-dependent induction of MCF-7 cell proliferation was found to be 0.85ng/ml corresponding to a Specific Activity of 1,176,470 IU/mg.
> 97 % pure by SDS-PAGE and HPLC
Less than 0.1 ng/ug (IEU/ug) of IGF-II.
7.5 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reconstitute with sterilized 18 M omega-cm water to a final concentration of at least 0.1 mg/ml.
After reconstitution, store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Alternate Names for Recombinant Human IGF-II Protein
chromosome 11 open reading frame 43
insulin-like growth factor 2 (somatomedin A)
insulin-like growth factor II
insulin-like growth factor type 2
IGF-2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
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