IGF-II Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

IGF-II Antibody Summary

Immunogen
Purified recombinant mouse IGF2 protein
Localization
Secreted protein
Specificity
Detects a band at approximately 20kDa. Based on ELISA, this has a 25% cross-reactivity to human IGF2.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IGF2
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Positive Control
MCF-7 Lysate (NB820-59465)

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS and 5% Trehalose
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IGF-II Antibody

  • C11orf43
  • chromosome 11 open reading frame 43
  • FLJ22066
  • FLJ44734
  • IGF2
  • IGF-2
  • IGFII
  • IGF-II
  • insulin-like growth factor 2 (somatomedin A)
  • insulin-like growth factor II
  • insulin-like growth factor type 2
  • MSA
  • PP9974
  • somatomedin-A

Background

Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share approx imately 70% amino acid sequence identity. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular mass of approximately 7.4 kDa. Mouse and human IGF-II share 91% sequence identity. Insulin-like growth factor II has autocrine, paracrine, and endocrine functions. It is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney cells, and MCF-7 human breast carcinoma cells.2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IGF2
Entrez