IGF-I R [p Tyr1165, p Tyr1166] Antibody

Images

 
Western Blot: IGF-I R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Analysis of extracts from 293 cells untreated or treated with insulin using IGF-1R(Phospho-Tyr1165/Tyr1166) antibody.
Immunocytochemistry/ Immunofluorescence: IGF-I R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Staining of methanol-fixed MCF cells using IGF-1R(Phospho-Tyr1165/Tyr1166) antibody.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

IGF-I R [p Tyr1165, p Tyr1166] Antibody Summary

Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human IGF-1R around the phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-YP-YP-R-K).
Modification
p Tyr1165, p Tyr1166
Specificity
IGF-1R (specific to Phospho-Tyr1165/Tyr1166) detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1165/tyrosine1166.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IGF1R
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Positive Control
IGF-I R Lysate (NBL1-11867)
Publications
Read Publication using
NB100-81983 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IGF-I R [p Tyr1165, p Tyr1166] Antibody

  • CD221 antigen
  • CD221
  • EC 2.7.10
  • EC 2.7.10.1
  • IGF1R
  • IGF-I R
  • IGF-I receptor
  • IGFIR
  • IGF-IR
  • IGFR
  • insulin-like growth factor 1 receptor
  • Insulin-like growth factor I receptor
  • JTK13
  • MGC142170
  • MGC142172
  • MGC18216
  • soluble IGF1R variant 1
  • soluble IGF1R variant 2

Background

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IGF-I R Antibody (NB100-81983)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


Filter By Application
WB
(1)
All Applications
Filter By Species
Human
(1)
All Species
Showing Publication 1 - 1 of 1.
Publication using NB100-81983 Applications Species
Welsink T Schomburg L. Development and Diagnostic Application of a Novel Quantitative Testfor Determination and Characterization of Autoantibodies againstInsulin-like Growth Factor 1 Receptor. Thesis. 2015 (WB, Human) WB Human

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol IGF1R
Entrez
Uniprot