Alternate Names for IGF-I R [p Tyr1165, p Tyr1166] Antibody
insulin-like growth factor 1 receptor
Insulin-like growth factor I receptor
soluble IGF1R variant 1
soluble IGF1R variant 2
There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for IGF-I R Antibody (NB100-81983)(1)
We have publications tested in 1 confirmed species: Human.
We have publications tested in 1 application: WB.
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Publication using NB100-81983
Welsink T Schomburg L. Development and Diagnostic Application of a Novel Quantitative Testfor Determination and Characterization of Autoantibodies againstInsulin-like Growth Factor 1 Receptor. Thesis. 2015 (WB, Human)
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