IGF-I R [p Tyr1161] Antibody

Images

 
Western Blot: IGF-I R [p Tyr1161] Antibody [NB100-81982] - Western blot analysis using IGF-1R (Ab-1161), Line 1, 2 and 3) and IGF-I R [p Tyr1161] Antibody, Line 4 and 5).
Immunocytochemistry/ Immunofluorescence: IGF-I R [p Tyr1161] Antibody [NB100-81982] - Staining of methanol-fixed MCF7 cells usingIGF-I R [p Tyr1161] Antibody
Immunohistochemistry: IGF-I R [p Tyr1161] Antibody [NB100-81982] - Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using IIGF-I R [p Tyr1161] Antibody

Product Details

Summary
Product Discontinued
View other related IGF-I R Primary Antibodies

Order Details


    • Catalog Number
      NB100-81982
    • Availability
      Product Discontinued

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IGF-I R [p Tyr1161] Antibody Summary

Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human IGF-1R around the phosphorylation site of tyrosine 1161 (D-I-YP-E-T).
Modification
p Tyr1161
Specificity
IGF-1R (specific to Phospho-Tyr1161) detects endogenous levels of IGF-1R only when phosphorylated at tyrosine1161.
Clonality
Polyclonal
Host
Rabbit
Gene
IGF1R
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Positive Control
IGF-I R Lysate (NBL1-11867)

Reactivity Notes

This antibody is reactive against Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IGF-I R [p Tyr1161] Antibody

  • CD221 antigen
  • CD221
  • EC 2.7.10
  • EC 2.7.10.1
  • IGF1R
  • IGF-I R
  • IGF-I receptor
  • IGFIR
  • IGF-IR
  • IGFR
  • insulin-like growth factor 1 receptor
  • Insulin-like growth factor I receptor
  • JTK13
  • MGC142170
  • MGC142172
  • MGC18216
  • soluble IGF1R variant 1
  • soluble IGF1R variant 2

Background

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IGF1R
Entrez
Uniprot