IGF-I R Antibody (3G5C1)


Western Blot: IGF-I R Antibody (3G5C1) [NB110-87052] - Analysis using IGF1R-Beta mouse mAb against truncated IGF1R recombinant protein.
Immunohistochemistry-Paraffin: IGF-I R Antibody (3G5C1) [NB110-87052] - Analysis of rectum cancer tissues using IGF1R-Beta mouse mAb with DAB staining.
Flow Cytometry: IGF-I R Antibody (3G5C1) [NB110-87052] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HeLa (B) cells using IGF1 receptor antibody (dark blue). Isotype control shown in orange. An ...read more
Immunohistochemistry-Paraffin: IGF-I R Antibody (3G5C1) [NB110-87052] - Analysis of ovarian cancer tissues using IGF1R-Beta mouse mAb with DAB staining.

Product Details

Reactivity HuSpecies Glossary
Applications WB, ELISA, Flow, IHC, IHC-P
This product is unpurified. The exact concentration of antibody is not quantifiable.

Order Details

IGF-I R Antibody (3G5C1) Summary

Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli.
Membrane; Single-pass type I membrane protein.
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.03% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.


Application Notes
This IGF1 Receptor (3G5C1) antibody is useful for Western blot, Immunohistochemistry on paraffin-embedded sections and ELISA. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
96 kDa
Read Publications using
NB110-87052 in the following applications:

  • IHC
    3 publications
  • 3 publications
  • WB
    1 publication

Alternate Names for IGF-I R Antibody (3G5C1)

  • CD221 antigen
  • CD221
  • EC 2.7.10
  • EC
  • IGF1R
  • IGF-I receptor
  • IGF-IR
  • IGFR
  • insulin-like growth factor 1 receptor
  • Insulin-like growth factor I receptor
  • JTK13
  • MGC142170
  • MGC142172
  • MGC18216
  • soluble IGF1R variant 1
  • soluble IGF1R variant 2


IGF1 Receptor (insulin-like growth factor 1 receptor, IGF1R), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF1 and IGF2, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IGF-I R Antibody (NB110-87052)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IHC, IHC-P, WB.

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Showing Publications 1 - 8 of 8.
Publications using NB110-87052 Applications Species
Jori B, Kamps R, Xanthoulea S et al. Germ-line variants identified by next generation sequencing in a panel of estrogen and cancer associated genes correlate with poor clinical outcome in Lynch syndrome patients. Oncotarget. 2015 Oct 22 [PMID:26517685] (IHC-P, Human) IHC-P Human
Koo DH, Lee HJ, Ahn JH et al. Tau and PTEN status as predictive markers for response to trastuzumab and paclitaxel in patients with HER2-positive breast cancer Tumour Biol. 2015 Mar 01 [PMID:25725586] (IHC-P, Human) IHC-P Human
Jiwa Ls, Van Diest Pj, Hoefnagel Ld et al. Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases. BMC Cancer. 2014 Nov 27 [PMID:25417118] (IHC-P, Human) IHC-P Human
Vermeulen JF, van der Wall E, Witkamp AJ, van Diest PJ. Analysis of expression of membrane-bound tumor markers in ductal carcinoma in situ of the breast: paving the way for molecular imaging. Cell Oncol (Dordr) 2013 Jun 7 [PMID:23744486]
Vermeulen JF, Kornegoor R, van der Wall E et al. Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer PLoS One 2013 [PMID:23308200] (IHC, Human) IHC Human
Varewijck AJ, Brugts MP, Frystyk J et al. Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling Mol Cell Endocrinol 2012 Sep 7 [PMID:22982059] (IHC, Human) IHC Human
Vermeulen JF, van Brussel AS, van der Groep P et al. Immunophenotyping invasive breast cancer: paving the road for molecular imaging BMC Cancer 2012 Jun 13 [PMID:22695343] (IHC, Human) IHC Human
Kong KL, Kwong DL, Chan TH, Law SY, Chen L, Li Y, Qin YR, Guan XY. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut;61(1):33-42. 2012 Jan. [PMID:21813472] (WB, Human) WB Human

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for IGF-I R Antibody (NB110-87052). (Showing 1 - 1 of 1 FAQs).

  1. I ordered NB110-87052 and the website said that the concentration is mentioned on the vial, but it is not. Can you tell me what's the (antibody) concentration in Lot 81210 and 3G5C1?
    • The formulation for the product is ascites fluid therefore the concentration is unknown because we cannot typically measure an accurate concentration with ascites that hasn't been purified.

Secondary Antibodies


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Contact Information

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Gene Symbol IGF1R

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