ICAM-1/CD54 Antibody (HM.2) [Biotin]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51696B
    • Availability
      Product Discontinued

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ICAM-1/CD54 Antibody (HM.2) [Biotin] Summary

Immunogen
The monoclonal HM.2 antibody reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ICAM1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered biotinylated antibody solution in PBS and 0.1% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for ICAM-1/CD54 Antibody (HM.2) [Biotin]

  • BB2
  • CD54 antigen
  • CD54
  • cell surface glycoprotein P3.58
  • human rhinovirus receptor
  • ICAM1
  • ICAM-1
  • intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
  • intercellular adhesion molecule 1
  • Major group rhinovirus receptor
  • P3.58

Background

The monoclonal HM.2 antibody reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1). The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset; it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43. ICAM-1 is an essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leucocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments. ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional ICAM-1/CD54 Products

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Diseases for ICAM-1/CD54 Antibody (NBP1-51696B)

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Bioinformatics

Gene Symbol ICAM1
Entrez