Huntingtin Antibody

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Immunoprecipitation: Huntingtin Antibody [NBP1-47279] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Huntingtin antibody NBP1-47279 used for IP ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-47279
    • Availability
      Product Discontinued

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Huntingtin Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 2300 and 2350 of human Huntingtin using the numbering given in entry NP_002102.4 (GeneID 3064).
Clonality
Polyclonal
Host
Rabbit
Gene
HTT
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 2-5 ug/mg lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Huntingtin Antibody

  • HD protein
  • huntingtin (Huntington disease)
  • huntingtin
  • IT15HDHuntington disease protein

Background

Huntingtin (also known as Huntington's disease protein, Htt and HD protein) is the protein product of a disease gene linked to Huntington's disease, a neuro-degenerative disorder characterized by loss of striatal neurons. This may be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product (see partial protein sequence below). The huntingtin gene locus is large, spanning 180 kb and consisting of 67 exons. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. Normal huntingtin protein shows a cytoplasmic localization. This protein is widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional Huntingtin Products

Bioinformatics Tool for Huntingtin Antibody (NBP1-47279)

Discover related pathways, diseases and genes to Huntingtin Antibody (NBP1-47279). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Huntingtin Antibody (NBP1-47279)

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PTMs for Huntingtin Antibody (NBP1-47279)

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Bioinformatics

Gene Symbol HTT
Entrez