Human Chitinase 3-like 1 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Chitinase 3-like 1 Quantikine ELISA Kit Summary

Background
The Quantikine Human CHI3L1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure CHI3L1 in cell culture supernates, serum, plasma, and urine. It contains NS0-expressed recombinant human CHI3L1 and antibodies raised against recombinant human CHI3L1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural CHI3L1 showed dose response curves t...hat were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human CHI3L1.
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Specificity
Natural and recombinant human CHI3L1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CHI3L1

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DC3L10.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Chitinase 3-like 1 Quantikine ELISA Kit

  • AW208766
  • Brp39
  • CHI3L1
  • Chitinase 3 like 1
  • Chitinase 3-like 1
  • gp39
  • HCgp39
  • YKL-40

Background

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Chitinase 3-like 1 (DC3L10)(22)

We have publications tested in 1 confirmed species: Human.


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Human
(21)
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Showing Publications 1 - 10 of 22. Show All 22 Publications.
Publications using DC3L10 Applications Species
P Kušnierová, D Zeman, P Hradílek, O Zapletalov, D Stejskal Determination of chitinase 3-like 1 in cerebrospinal fluid in multiple sclerosis and other neurological diseases PLoS ONE, 2020;15(5):e0233519. 2020 [PMID: 32437412] (Human) Human
EA Hoste, ST Vaara, J De Loor, M Haapio, L Nuytinck, K Demeyere, V Pettilä, E Meyer, Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort Crit Care, 2020;24(1):144. 2020 [PMID: 32276601] (Human) Human
HJ Whitwell, J Worthingto, O Blyuss, A Gentry-Mah, A Ryan, R Gunu, J Kalsi, U Menon, I Jacobs, A Zaikin, JF Timms Improved early detection of ovarian cancer using longitudinal multimarker models Br. J. Cancer, 2020;0(0):. 2020 [PMID: 31937926]
S Palmqvist, PS Insel, E Stomrud, S Janelidze, H Zetterberg, B Brix, U Eichenlaub, JL Dage, X Chai, K Blennow, N Mattsson, O Hansson Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease EMBO Mol Med, 2019;0(0):e11170. 2019 [PMID: 31709776] (Human) Human
H Lowes, A Pyle, M Duddy, G Hudson Cell-free mitochondrial DNA in progressive multiple sclerosis Mitochondrion, 2018;0(0):. 2018 [PMID: 30098422] (Human) Human
M Olsson, J Ärlig, J Hedner, K Blennow, H Zetterberg Sleep Deprivation and CSF Biomarkers for Alzheimer Disease Sleep, 2018;0(0):. 2018 [PMID: 29425372] (Human) Human
CS Jensen, E Portelius, P Høgh, L Wermuth, K Blennow, H Zetterberg, SG Hasselbalc, AH Simonsen Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease Alzheimers Dement (N Y), 2017;3(2):284-290. 2017 [PMID: 29067334] (Human) Human
A Pikwer, M Castegren, S Namdar, K Blennow, H Zetterberg, N Mattsson Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer's disease, and neuronal injury in humans: a cohort study J Neuroinflammation, 2017;14(1):193. 2017 [PMID: 28962579] (Human) Human
J Salomon, ? Matusiak, D Nowicka-Su, JC Szepietows Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis Mediators Inflamm., 2017;2017(0):9538451. 2017 [PMID: 28932021] (Human) Human
J Salomon, ? Matusiak, D Nowicka-Su, JC Szepietows Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis J Immunol Res, 2017;2017(0):5746031. 2017 [PMID: 28660216] (Human) Human
Show All 22 Publications.

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Product General Protocols

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FAQs for Chitinase 3-like 1 (DC3L10). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DC3L10

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Bioinformatics

Gene Symbol CHI3L1