Human Chitinase 3-like 1 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Chitinase 3-like 1 Quantikine ELISA Kit Summary

• Background: The Quantikine Human CHI3L1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure CHI3L1 in cell culture supernates, serum, plasma, and urine. It contains NS0-expressed recombinant human CHI3L1 and antibodies raised against recombinant human CHI3L1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural CHI3L1 showed dose response curves t...hat were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human CHI3L1.
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• Specificity: Natural and recombinant human CHI3L1
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CHI3L1

Applications/Dilutions

• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Chitinase 3-like 1 Quantikine ELISA Kit

• AW208766
• Brp39
• CHI3L1
• Chitinase 3 like 1
• Chitinase 3-like 1
• gp39
• HCgp39
• YKL-40

Background

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Chitinase 3-like 1 (DC3L10)(22)

Publications using DC3L10

• P Kušnierová, D Zeman, P Hradílek, O Zapletalov, D Stejskal Determination of chitinase 3-like 1 in cerebrospinal fluid in multiple sclerosis and other neurological diseases PLoS ONE, 2020;15(5):e0233519. 2020 [PMID: 32437412] (Human)
• EA Hoste, ST Vaara, J De Loor, M Haapio, L Nuytinck, K Demeyere, V Pettilä, E Meyer, Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort Crit Care, 2020;24(1):144. 2020 [PMID: 32276601] (Human)
• HJ Whitwell, J Worthingto, O Blyuss, A Gentry-Mah, A Ryan, R Gunu, J Kalsi, U Menon, I Jacobs, A Zaikin, JF Timms Improved early detection of ovarian cancer using longitudinal multimarker models Br. J. Cancer, 2020;0(0):. 2020 [PMID: 31937926]
• S Palmqvist, PS Insel, E Stomrud, S Janelidze, H Zetterberg, B Brix, U Eichenlaub, JL Dage, X Chai, K Blennow, N Mattsson, O Hansson Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease EMBO Mol Med, 2019;0(0):e11170. 2019 [PMID: 31709776] (Human)
• H Lowes, A Pyle, M Duddy, G Hudson Cell-free mitochondrial DNA in progressive multiple sclerosis Mitochondrion, 2018;0(0):. 2018 [PMID: 30098422] (Human)
• M Olsson, J Ärlig, J Hedner, K Blennow, H Zetterberg Sleep Deprivation and CSF Biomarkers for Alzheimer Disease Sleep, 2018;0(0):. 2018 [PMID: 29425372] (Human)
• CS Jensen, E Portelius, P Høgh, L Wermuth, K Blennow, H Zetterberg, SG Hasselbalc, AH Simonsen Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease Alzheimers Dement (N Y), 2017;3(2):284-290. 2017 [PMID: 29067334] (Human)
• A Pikwer, M Castegren, S Namdar, K Blennow, H Zetterberg, N Mattsson Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer's disease, and neuronal injury in humans: a cohort study J Neuroinflammation, 2017;14(1):193. 2017 [PMID: 28962579] (Human)
• J Salomon, ? Matusiak, D Nowicka-Su, JC Szepietows Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis Mediators Inflamm., 2017;2017(0):9538451. 2017 [PMID: 28932021] (Human)
• J Salomon, ? Matusiak, D Nowicka-Su, JC Szepietows Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis J Immunol Res, 2017;2017(0):5746031. 2017 [PMID: 28660216] (Human)
• P Jørgen Jen, L Østergaard, JM Czarna Bah, S Modvig, K Fog, A Holm, B Rahbek Kor, S Gammeltoft Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy Sleep, 2017;40(1):. 2017 [PMID: 28364448] (Human)
• SR Langley, K Willeit, A Didangelos, LP Matic, P Skroblin, J Barallobre, M Lengquist, G Rungger, A Kapustin, L Kedenko, C Molenaar, R Lu, T Barwari, G Suna, X Yin, B Iglseder, B Paulweber, P Willeit, J Shalhoub, G Pasterkamp, AH Davies, C Monaco, U Hedin, CM Shanahan, J Willeit, S Kiechl, M Mayr Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques J. Clin. Invest, 2017;0(0):. 2017 [PMID: 28319050] (Human)
• J De Loor, I Herck, K Francois, A Van Wesema, L Nuytinck, E Meyer, EA Hoste Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study Ann Intensive Care, 2017;7(1):24. 2017 [PMID: 28251598] (Human)
• Viktoria Johansson Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders Eur Arch Psychiatry Clin Neurosci, 2016;0(0):. 2016 [PMID: 28039552] (Human)
• Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis JCI Insight, 2016;1(20):e90954. 2016 [PMID: 27942596] (Human)
• Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application BMC Med Res Methodol, 2016;16(1):154. 2016 [PMID: 27842498] (Human)
• Annette Eyking MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer PLoS ONE, 2016;11(6):e0156871. 2016 [PMID: 27271572] (Human)
• The impact of acute aerobic exercise on chitinase 3-like protein 1 and intelectin-1 expression in obesity Exp. Biol. Med. (Maywood), 2016;241(2):216-21. 2016 [PMID: 26316585] (Human)
• Fantino E, Gangell C, Hartl D, Sly P Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease. BMC Pulm Med, 2014;14(0):28. 2014 [PMID: 24576297] (Human)
• Yan, Cong, Ding, Xinchun, Wu, Lingyan, Yu, Menggang, Qu, Peng, Du, Hong Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans. PLoS ONE, 2013;8(4):e61984. 2013 [PMID: 23613996] (Human)
• Kim HR, Jun CD, Lee KS, Cho JH, Jeong ET, Yang SH, Lee YJ, Park DS Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease. Cytokine, 2012;58(3):336-43. 2012 [PMID: 22480951] (Human)
• Hector A, Kormann MS, Mack I, Latzin P, Casaulta C, Kieninger E, Zhou Z, Yildirim AÖ, Bohla A, Rieber N, Kappler M, Koller B, Eber E, Eickmeier O, Zielen S, Eickelberg O, Griese M, Mall MA, Hartl D The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease. PLoS ONE, 2011;6(9):e24399. 2011 [PMID: 21949714] (Human)

FAQs for Chitinase 3-like 1 (DC3L10). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: CHI3L1