HTRA2/Omi Antibody

Images

 
Western Blot: HTRA2/Omi Antibody [NBP1-77195] - Human colon cell lysates with OMI antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry-Paraffin: HTRA2/Omi Antibody [NBP1-77195] - Human colon tissue with HtrA2 antibody at 10 ug/ml.
Immunofluorescence: HTRA2/Omi Antibody [NBP1-77195] - Immunofluorescence of OMI in human colon tissue with OMI antibody at 20 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

HTRA2/Omi Antibody Summary

Immunogen
Antibody was raised against a peptide corresponding to 15 amino acids near the N-terminus of human OMI. The immunogen is located within amino acids 120 - 170 of OMI.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HTRA2
Purity
Ion exchange chromatography
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence
Application Notes
OMI antibody can be used for detection of OMI by Western blot at 0.5 to 1 mg/ml.
Control Peptide
HTRA2/Omi Peptide (NBP1-77195PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Ion exchange chromatography

Alternate Names for HTRA2/Omi Antibody

  • High temperature requirement protein A2
  • HtrA serine peptidase 2
  • HTRA2
  • HtrA-like serine protease
  • Omi
  • OMIOmi stress-regulated endoprotease
  • PARK13EC 3.4.21.108
  • PRSS25
  • PRSS25serine, 25
  • Serine protease 25
  • serine protease HTRA2, mitochondrial
  • Serine proteinase OMI

Background

Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Bioinformatics

Gene Symbol HTRA2
Entrez
Uniprot