Hsp90B2P Antibody

Images

 
Immunohistochemistry-Paraffin: Hsp90B2P Antibody [NBP1-02459] - Staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ...read more
Immunohistochemistry-Paraffin: Hsp90B2P Antibody [NBP1-02459] - Human kidney

Product Details

Summary
Reactivity Hu, Mu, Rt, Ch, Dr, PmSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Hsp90B2P Antibody Summary

Immunogen
Synthetic peptide from human HSP90AA1 / Hsp90.
Specificity
Amino acids 289-300 of human Hsp90 protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HSP90B2P
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2500
  • ELISA 1:5000-1:25000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 2.5-5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Potassium Phosphate (pH 7.2) and 0.15M NaCl
Preservative
0.01% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Hsp90B2P Antibody

  • GRP94B
  • GRP94P1
  • heat shock protein 90kDa beta (Grp94), member 2, pseudogene
  • HsGrp94b
  • HSP
  • HSPCP2
  • TRA1P1
  • TRAP1

Background

Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Array NBP1-02459

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Bioinformatics

Gene Symbol HSP90B2P
Entrez