Hsp70 / Hsc70 Antibody

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Immunohistochemistry-Paraffin: HSP70 / HSC70 Antibody [NBP1-97872] - Analysis of human spleen, neutrophils tissue stained with HSC70/HSP70, pAb at 10ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Ch, Dr, Fi, GP, Ha, Pl, Pm, Sh, YeSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit

Order Details

Hsp70 / Hsc70 Antibody Summary

Immunogen
Synthetic peptide corresponding to a portion of rat Hsp70.
Clonality
Polyclonal
Host
Rabbit
Gene
HSPA1A
Purity
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
PBS and 50% Glycerol
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Recognizes Human, Mouse, Rat, Bovine, Canine, Chicken, Drosophila, Fish, Guinea Pig, Hamster, Primate, Pig, Plant, Rabbit, Sheep and Yeast HSC70 (HSP70).

Alternate Names for Hsp70 / Hsc70 Antibody

  • heat shock 70kDa protein 1A
  • HSP70-1
  • HSP70-1A
  • HSP70I
  • HSP72
  • HSPA1
  • HSPA1A

Background

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on Hsp70 / Hsc70.

Hsp70/Hsc70 - A chaperone for protein folding and autophagy
The heat shock protein 70 (Hsp70) family are a group of chaperones involved in various cellular processes including protein folding and protein degradation. In addition to maintaining normal cellular homeostasis by processing newly synthesized pro...  Read full blog post.

Contact Information

Product PDFs

Bioinformatics

Gene Symbol HSPA1A
Uniprot

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