Western Blot: HLA DRB1 Antibody [H00003123-D01P] - Analysis of HLA-DRB1 expression in transfected 293T cell line by HLA-DRB1 polyclonal antibody.Lane 1: HLA-DRB1 transfected lysate(30.00 KDa).Lane 2: Non-transfected ...read more
Quality control test: Antibody reactive against mammalian transfected lysate.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for HLA DRB1 Antibody
HLA class II antigen beta chain
HLA class II histocompatibility antigen, DR-1 beta chain
human leucocyte antigen DRB1
leucocyte antigen DR beta 1 chain
leucocyte antigen DRB1
lymphocyte antigen DRB1
major histocompatibility complex, class II, DR beta 1
MHC class II antigen DRB1*1
MHC class II antigen DRB1*10
MHC class II antigen DRB1*11
MHC class II antigen DRB1*12
MHC class II antigen DRB1*13
MHC class II antigen DRB1*14
MHC class II antigen DRB1*15
MHC class II antigen DRB1*16
MHC class II antigen DRB1*3
MHC class II antigen DRB1*4
MHC class II antigen DRB1*7
MHC class II antigen DRB1*8
MHC class II antigen DRB1*9
MHC class II antigen HLA-DR13
MHC class II HLA-DR beta 1 chain
MHC class II HLA-DR-beta cell surface glycoprotein
MHC class II HLA-DRw10-beta
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for HLA DRB1 Antibody (H00003123-D01P). (Showing 1 - 1 of 1 FAQ).
We are interested in custom labeling our antibodies to be able to integrate new markers into already existing multicolor FACS panels. We would be glad to receive pricing and general order information for anti-HLA-DRB1 and anti-HLA-DRB5. To estimate expenses for future antibody labeling orders it would be helpful to know on what basis (amount, type, etc.) the price is going to be calculated. Right now the antibodies are still in mouse ascites. Would it be possible to integrate the elution of the antibodies from the ascites before labeling as part of the service agreement?
While we do not generally do this kind of custom purification unless it is for very large amounts of antibody, we do have a number of kits available that may be of use to you. Since an antibody that is still in ascites can not be labeled, it will need to be purified. A list of our kits available for this can be found at the following link: AbSelect. Once the antibodies are purified, they can be labeled with any number of different colors. A list of these kits for labeling can be found at the following link: Lightning-Link.