Histone H2B Antibody Summary
KLH-conjugated, synthetic peptide APAPKAcKGSKKAITK corresponding to 7-20 amino acid of human Histone H2B member F. The immunizing sequence has 13 out of 14 identical amino acids in mouse, chicken and rat.
Recognizes human acetylated Histone 2B, Mr 15kD. Species sequence identity: mouse, chicken and rat.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Serum, 0.05% sodium azide, 30% glycerol.
0.05% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.
Human, Chicken, Mouse, Rat
Changes in chromatin structure play a key role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is acetylated in the N-terminal region, primary at lysines 5, 12, 15, and 20 (3). Ubiquitylation of histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4). Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of cell apoptosis and meiosis (5).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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