Histone Deacetylase 4/HDAC4 Antibody

Images

 
Western Blot: HDAC4 Antibody [NB100-81950] - Analysis of extracts from HepG2 cells using HDAC4 (Ab-632) antibody
Immunocytochemistry/ Immunofluorescence: HDAC4 Antibody [NB100-81950] - Staining of methanol-fixed Hela cells using HDAC4 (Ab-632) antibody
Western Blot: HDAC4 Antibody [NB100-81950] - Western blot analysis of extracts from Jurkat cells using HDAC4 (Ab-632) antibody (Lane 1 and 2) and HDAC4 (phospho-Ser632) antibody (Lane 3 and 4).

Order Details


    • Catalog Number
      NB100-81950
    • Availability
      Product Discontinued

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Histone Deacetylase 4/HDAC4 Antibody Summary

Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human HDAC4 around aa. 632 (A-Q-S-S-P).
Specificity
HDAC4 (specific to a.a. 632) detects endogenous levels of total HDAC4 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
HDAC4
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Theoretical MW
140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Histone Deacetylase 4/HDAC4 Lysate (NBL1-11482)

Reactivity Notes

This antibody is reactive against Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Histone Deacetylase 4/HDAC4 Antibody

  • HA6116
  • HD4EC 3.5.1.98
  • HDAC4
  • HDAC-A
  • HDACABDMR
  • Histone Deacetylase 4
  • histone deacetylase A
  • KIAA0288AHO3

Background

Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HDAC4
Entrez
Uniprot