HIF-2 alpha/EPAS1 Antibody (318404) [Biotin]

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NBP2-54805B
    • Availability
      Product Discontinued

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HIF-2 alpha/EPAS1 Antibody (318404) [Biotin] Summary

Immunogen
E. coli-derived recombinant human HIF-2 alpha /EPAS1
Ser543-Thr870
Accession # Q99814
Specificity
Detects human HIF-2 alpha /EPAS1 in Western blots.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
EPAS1
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Control
HIF-2 alpha/EPAS1 Lysate (NBP2-64985)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS.
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for HIF-2 alpha/EPAS1 Antibody (318404) [Biotin]

  • Basic-helix-loop-helix-PAS protein MOP2
  • BHLHE73
  • bHLHe73ECYT4
  • Class E basic helix-loop-helix protein 73
  • endothelial PAS domain protein 1
  • endothelial PAS domain-containing protein 1
  • EPAS1
  • EPAS-1
  • HIF 2A
  • HIF-1alpha-like factor
  • HIF2 alpha
  • HIF-2 alpha
  • hif2a angiogenesis
  • HIF2A
  • HIF2AHIF-2-alpha
  • HLF
  • HLFHIF-1-alpha-like factor
  • hypoxia-inducible factor 2 alpha
  • Hypoxia-inducible factor 2-alpha
  • Member of PAS protein 2
  • MOP2
  • MOP2HIF2-alpha
  • PASD2PAS domain-containing protein 2

Background

The hypoxia-inducible transcription factor 2a (HIF-2a) is stabilized in hypoxic tissue and, similarly to HIF-1a, complexes with Aryl hydrocarbon receptor nuclear translocator (ARNT). Both the HIF-1 and HIF-2 complexes bind hypoxia-response elements (HREs) in the promoters of many genes involved in adapting to an environment of insufficient oxygen or hypoxia. HIF-1 and HIF-2 do not appear completely redundant. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the potentially broad impact of gene regulation by both HIF-1a and HIF-2a

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP2-54805B
Species: Hu
Applications: WB

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Video Protocols

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for HIF-2 alpha/EPAS1 Antibody (NBP2-54805B)

Discover related pathways, diseases and genes to HIF-2 alpha/EPAS1 Antibody (NBP2-54805B). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for HIF-2 alpha/EPAS1 Antibody (NBP2-54805B)

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PTMs for HIF-2 alpha/EPAS1 Antibody (NBP2-54805B)

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Blogs on HIF-2 alpha/EPAS1.

HIF-2 alpha: HIF1A's Homologue with Similar and Divergent Functions
HIF-2 alpha is a member of the heterodimeric hypoxia-inducible factors/HIFs family (HIF-1, HIF-2, and HIF-3) which contains a common beta subunit but differ in their alpha subunits. Also called as EPAS1 or Mop2, HIF-2 alpha regulates cellular adapt...  Read full blog post.

HIF-2 alpha, Tumor Suppression and Cell Survival
HIF-2 alpha is one subunit within the HIF-2 nuclear protein that regulates cellular responses to hypoxia (low oxygen tension conditions). Hydroxylation post-translational modifications on particular HIF residues target them for degradation. Luo, et al...  Read full blog post.

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Bioinformatics

Gene Symbol EPAS1